Gary W Cline Selected Research

Acyl Coenzyme A (Acyl CoA)

1/2018	In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia.
1/2011	Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates.
10/2009	Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition.
4/2007	n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.
7/2005	Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.
6/2005	Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance.
3/2004	Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.
4/2003	Skeletal muscle lipid metabolism with obesity.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Gary W Cline Research Topics

Disease

53	Insulin Resistance 01/2022 - 03/2002
20	Type 2 Diabetes Mellitus (MODY) 01/2022 - 03/2002
13	Non-alcoholic Fatty Liver Disease 01/2021 - 03/2006
12	Hyperglycemia 01/2020 - 10/2002
12	Obesity 02/2019 - 04/2003
9	Body Weight (Weight, Body) 01/2022 - 05/2007
6	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/2020 - 06/2012
5	Hypertriglyceridemia 10/2019 - 05/2002
4	Glucose Intolerance 12/2020 - 06/2005
4	Fatty Liver 10/2017 - 07/2005
3	Hyperinsulinism (Hyperinsulinemia) 01/2020 - 12/2004
3	Hyperphagia (Overeating) 02/2019 - 04/2010
3	Inflammation (Inflammations) 01/2019 - 05/2007
3	Hypoglycemia (Reactive Hypoglycemia) 01/2019 - 04/2007
3	Weight Gain 07/2016 - 01/2013
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2016 - 07/2007
2	Weight Loss (Weight Reduction) 01/2020 - 05/2012
2	Overweight 01/2020 - 04/2003
2	Pinta 11/2019 - 10/2017
2	Starvation 11/2019 - 11/2018
2	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 02/2017 - 07/2014
2	Hyperlipidemias (Hyperlipidemia) 01/2015 - 05/2007
2	Insulinoma 12/2013 - 09/2011
1	Adenocarcinoma of Lung 12/2019
1	Necrosis 01/2019
1	Poisoning 01/2019

Drug/Important Bio-Agent (IBA)

36	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 05/2002
26	LipidsIBA 01/2022 - 03/2002
25	Insulin (Novolin)FDA Link 01/2021 - 03/2002
19	Triglycerides (Triacylglycerol)IBA 01/2021 - 03/2002
13	Fatty Acids (Saturated Fatty Acids)IBA 12/2018 - 03/2002
11	DiglyceridesIBA 10/2020 - 07/2005
8	Acetyl Coenzyme A (Acetyl-CoA)IBA 11/2018 - 03/2006
8	Acyl Coenzyme A (Acyl CoA)IBA 01/2018 - 04/2003
5	Protein Kinase C-epsilonIBA 01/2022 - 08/2007
5	LeptinIBA 01/2020 - 05/2002
5	GlycogenIBA 01/2020 - 10/2002
5	Liver GlycogenIBA 01/2020 - 12/2004
5	EnzymesIBA 12/2018 - 03/2004
4	CarbohydratesIBA 01/2021 - 07/2007
4	Coenzyme A (CoA)IBA 11/2018 - 03/2004
4	CytokinesIBA 01/2017 - 09/2005
4	Antisense OligonucleotidesIBA 05/2013 - 03/2006
3	Transcription Factors (Transcription Factor)IBA 01/2021 - 04/2007
3	Nonesterified Fatty Acids (NEFA)IBA 01/2020 - 12/2004
3	Lactic Acid (Lactate)FDA LinkGeneric 01/2020 - 09/2014
3	Amino Acids FDA Link 12/2019 - 04/2007
3	Alanine (L-Alanine)FDA Link 11/2019 - 04/2007
3	FructoseIBA 10/2019 - 01/2013
3	Acetates (Acetic Acid Esters)FDA Link 02/2019 - 07/2014
3	Tyrosine (L-Tyrosine)FDA Link 01/2019 - 09/2005
3	Interleukin-6 (Interleukin 6)IBA 01/2019 - 09/2005
3	Pyruvic Acid (Pyruvate)IBA 10/2017 - 04/2007
3	Phosphates (Orthophosphate)IBA 10/2016 - 07/2005
3	Glycerol (Glycerine)FDA LinkGeneric 07/2014 - 03/2002
3	AcyltransferasesIBA 06/2010 - 07/2005
2	CeramidesIBA 12/2020 - 11/2014
2	Insulin ReceptorIBA 12/2020 - 09/2005
2	naxagolideIBA 11/2020 - 01/2020
2	Glucagon (Glukagon)FDA Link 01/2020 - 12/2004
2	Pyruvate CarboxylaseIBA 11/2019 - 07/2013
2	GhrelinIBA 02/2019 - 01/2016
2	PhosphoenolpyruvateIBA 01/2019 - 07/2005
2	Sucrose (Saccharose)IBA 12/2018 - 07/2005
2	Acetyl-CoA CarboxylaseIBA 12/2018 - 10/2007
2	dihydrotetrabenazineIBA 12/2018 - 10/2018
2	Adenosine Triphosphate (ATP)IBA 01/2018 - 10/2016
2	Metformin (Glucophage)FDA LinkGeneric 01/2018 - 06/2014
2	Protein Kinases (Protein Kinase)IBA 05/2013 - 05/2007
2	Insulin Receptor Substrate ProteinsIBA 12/2008 - 12/2002
2	AdiponectinIBA 07/2007 - 11/2005
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2007 - 05/2007
2	Deoxyglucose (2 Deoxy D glucose)IBA 05/2007 - 11/2004
2	PPAR alphaIBA 04/2007 - 09/2005
2	Malonyl Coenzyme A (Malonyl CoA)IBA 03/2006 - 03/2004
2	Phosphatidylinositols (Phosphatidylinositol)IBA 09/2005 - 07/2003
1	Pharmaceutical PreparationsIBA 01/2022
1	Phosphotransferases (Kinase)IBA 12/2020
1	microsomal triglyceride transfer proteinIBA 12/2020
1	O(4)-methylthymidine triphosphateIBA 12/2020
1	IsotopesIBA 01/2020
1	Triiodothyronine (Liothyronine)FDA LinkGeneric 01/2020
1	Dopamine (Intropin)FDA LinkGeneric 01/2020
1	Proteins (Proteins, Gene)FDA Link 12/2019
1	Cyclin B1IBA 12/2019
1	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA 01/2019
1	Histidine (L-Histidine)FDA Link 01/2019
1	Histamine (Histamine Dihydrochloride)FDA Link 01/2019
1	GlucokinaseIBA 01/2019
1	GlucocorticoidsIBA 01/2019
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2019
1	Essential Amino AcidsIBA 01/2019
1	AminesIBA 01/2019
1	Levodopa (L Dopa)FDA LinkGeneric 01/2019
1	IncretinsIBA 01/2019
1	phenethylamineIBA 01/2019

Therapy/Procedure

6	Therapeutics 01/2020 - 05/2002
1	Oral Administration 01/2022
1	Bariatric Surgery 01/2021
1	Ketogenic Diet 01/2020